Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2
Journal of natural products, 2017•ACS Publications
The structures of 12 new “enantiomeric”-like abyssomicin metabolites (abyssomicins M–X)
from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an
unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the
first reported naturally occurring linear spirotetronate. Metabolite structures were determined
based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2
genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an
unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the
first reported naturally occurring linear spirotetronate. Metabolite structures were determined
based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2
genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
The structures of 12 new “enantiomeric”-like abyssomicin metabolites (abyssomicins M–X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
ACS Publications以上显示的是最相近的搜索结果。 查看全部搜索结果