Potential involvement of the extracranial venous system in central nervous system disorders and aging

R Zivadinov, CP Chung - BMC medicine, 2013 - Springer
… -designed, blinded, randomized and controlled clinical trials. … of CCSVI, it was recently
proposed that funding of CCSVI … Nevertheless, the concept of CCSVI has triggered an intense …

[PDF][PDF] Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study

AM Malagoni, R Galeotti, E Menegatti, F Manfredini… - Int Angiol, 2010 - researchgate.net
… or surgical assessment and blinded with respect to patients’ vascular outcome. Either the
patients or the assessor of fatigue did not know the results of CCSVI monitored by means of …

[HTML][HTML] Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with …

K Dolic, K Marr, V Valnarov, MG Dwyer, E Carl… - Functional …, 2011 - ncbi.nlm.nih.gov
CCSVI diagnostic approach is that DS is a highly operator-dependent imaging modality and
not easy to blind in … was to investigate the frequency of CCSVI in MS patients and HCs using …

Venous drainage in multiple sclerosis: a combined MRI and ultrasound study

F Doepp, JT Würfel, CF Pfueller, JM Valdueza… - Neurology, 2011 - AAN Enterprises
… the postulated 100% prevalence of CCSVI criteria in MS. MRV … and MS, favoring the rejection
of the CCSVI hypothesis. … sonographers (FD and SJS), blinded for the MRV results and for …

[HTML][HTML] Chronic cerebrospinal venous insufficiency in multiple sclerosis: a failed concept

N Kugler, PJ Patel, CJ Lee - Vascular Specialist International, 2015 - ncbi.nlm.nih.gov
… in multiple sclerosis” (CoSMo study) which attempted to validate the presence of CCSVI in
blinded, rigorously trained, and a consensus had to be obtained for DU diagnosis of CCSVI

[HTML][HTML] Sources of information and behavioral patterns in online health forums: observational study

F Sudau, T Friede, J Grabowski, J Koschack… - Journal of medical …, 2014 - jmir.org
… (CCSVI) hypothesis. After extracting all posts and then filtering relevant CCSVI posts between
… A key element in this process has been unlimited access to and intelligent use of health-…

I knew what was going to happen if I did nothing and so I was going to do something”: Faith, hope, and trust in the decisions of Canadians with multiple sclerosis to …

J Snyder, K Adams, VA Crooks, D Whitehurst… - BMC health services …, 2014 - Springer
CCSVI, Canadians continue to advocate for domestic access to CCSVI treatment and to travel
abroad for CCSVI … This loss of quality of life was the key motivation for some who reported …

Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study

T Sinnecker, I Bozin, J Dörr, CF Pfueller… - Multiple Sclerosis …, 2013 - journals.sagepub.com
… For the quantification of small cerebral veins in a blinded fashion… A further key point of this
study was the investigation of very … visibility is a consequence of CCSVI, leading to destruction …

Clinician-trialist rounds: 6. Testing for blindness at the end of your trial is a mug's game

DL Sackett - Clinical Trials, 2011 - journals.sagepub.com
… would suggest that our attempts to blind them had failed. … The key question in this Round is:
What are you really measuring … cerebrospinal venous insufficiency (CCSVI) by feeding all of …

Risk management for disease-modifying treatments in MS

M Trojano - Multiple Sclerosis Journal, 2011 - search.proquest.com
… -blind manner; only the neurological rater was blinded to … that NS findings described as
CCSVI are much less prevalent than … However replication is key, and we therefore genotyped the …