BACKGROUND: Although accurate risk prediction is essential in guiding treatment
decisions in primary prevention of atherosclerotic cardiovascular disease, the accuracy of
the Framingham Risk Score (recommended by a Canadian guideline) and the Pooled
Cohort Equations (recommended by US guidelines) has not been assessed in a large
contemporary Canadian population. Our primary objective was to assess the calibration and
discrimination of the Framingham Risk Score and Pooled Cohort Equations in Ontario …

Introduction: Although accurate risk estimation is essential in guiding treatment decisions in
primary prevention of atherosclerotic cardiovascular disease (CVD), the validity of the
Framingham Risk Score (FRS)(recommended by Canadian guidelines) and the Pooled
Cohort Equations (PCE)(recommended by US guidelines) has not been assessed in a large
contemporary Canadian population. Hypothesis: FRS and FCE are not well validated in the
Canadian diverse population. Methods: We conducted an observational study of Ontario …