Objective To investigate if the widely publicized warnings in 2003 from the US Food and
Drug Administration about a possible increased risk of suicidality with antidepressant use in
young people were associated with changes in antidepressant use, suicide attempts, and
completed suicides among young people. Design Quasi-experimental study assessing
changes in outcomes after the warnings, controlling for pre-existing trends. Setting
Automated healthcare claims data (2000-10) derived from the virtual data warehouse of 11 …

Authors: Miller M et al. Summary: This propensity score-matched cohort study used
population-based healthcare utilisation data from 162,625 US residents aged 10–64 years
with depression, all of whom had initiated antidepressant therapy with selective serotonin
reuptake inhibitors (SSRIs) at modal or at higher-than-modal doses between 1 January
1998 and 31 December 2010. Modal doses for citalopram, sertraline and fluoxetine were 20
mg/day, 50 mg/day and 20 mg/day, respectively. When the researchers examined the risk of …