New type of carriers based on grafted poly (ionic liquid) s was designed for delivery of
ionically attached salicylates (Sal). Choline derived ionic liquid monomeric units were
successfully introduced with various content in the side chains by the controlled radical
polymerization. Properly high amounts of ionic pharmaceutics in the polymer systems were
achieved by the well-fitted length and grafting degree of the side chains. In aqueous solution
the graft copolymers were self-assembled into the spherical superstructures with sizes up to …

Materials and Methods Materials. Methyl methacrylate (MMA) and 2-(hydroxyethyl)
methacrylate (HEMA)(both Alfa Aesar) were desiccated using 4 Å molecular sieves
(Chempur).[2-(methacryloyloxy) ethyl] trimethylammonium chloride (ChMA/Cl, 80% aq.
solution, Sigma-Aldrich) was concentrated to a constant weight by water evaporation.
Copper (I) bromide, copper (I) chloride, 2, 2′-bipyridine, sodium salicylate (NaSal),
tetrahydrofuran (THF), N, N, N′, N ″, N ″-pentamethyldiethyltriamine (PMDETA) and ethyl …