Abstract Several isoquinoline alkaloids (1-18), which have basic chemical structures as
protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on
AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE
activity with the $ IC_ {50} $ values ranging from $10.2 {\pm} 0.5\;{\mu} M $ to $24.5 {\pm}
1.6\;{\mu} M $, meanwhile, compound 14-17 exhibited strong inhibitory activity with $ IC_
{50} $ values from $2.1 {\pm} 0.2$ to $5.5 {\pm} 0.3\;{\mu} M $. Compounds 14-17 exhibited …

Abstract Several isoquinoline alkaloids (1-18), which have basic chemical structures as
protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on
AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE
activity with the IC50 values ranging from 10.2±0.5 µM to 24.5±1.6 µM, meanwhile,
compound 14-17 exhibited strong inhibitory activity with IC50 values from 2.1±0.2 to 5.5±0.3
µM. Compounds 14-17 exhibited selective inhibition for AChE compared with BuChE. The …