Circulating biomarkers for therapeutic monitoring of anti-cancer agents
HJ Janse van Rensburg, P Spiliopoulou… - The Oncologist, 2022 - academic.oup.com
HJ Janse van Rensburg, P Spiliopoulou, LL Siu
The Oncologist, 2022•academic.oup.comCirculating biomarkers have emerged as valuable surrogates for evaluating disease states
in solid malignancies. Their relative ease of access and rapid turnover has bolstered clinical
applications in monitoring treatment efficacy and cancer progression. In this review, the roles
of various circulating biomarkers in monitoring treatment response are described. Non-
specific markers of disease burden, tumor markers (eg CA 125, CEA, PSA, etc.), circulating
tumor cells, nucleic acids, exosomes, and metabolomic arrays are highlighted. Specifically …
in solid malignancies. Their relative ease of access and rapid turnover has bolstered clinical
applications in monitoring treatment efficacy and cancer progression. In this review, the roles
of various circulating biomarkers in monitoring treatment response are described. Non-
specific markers of disease burden, tumor markers (eg CA 125, CEA, PSA, etc.), circulating
tumor cells, nucleic acids, exosomes, and metabolomic arrays are highlighted. Specifically …
Abstract
Circulating biomarkers have emerged as valuable surrogates for evaluating disease states in solid malignancies. Their relative ease of access and rapid turnover has bolstered clinical applications in monitoring treatment efficacy and cancer progression. In this review, the roles of various circulating biomarkers in monitoring treatment response are described. Non-specific markers of disease burden, tumor markers (eg CA 125, CEA, PSA, etc.), circulating tumor cells, nucleic acids, exosomes, and metabolomic arrays are highlighted. Specifically, the discovery of each of these markers is reviewed, with examples illustrating their use in influencing treatment decisions, and barriers to their application noted where these exist. Finally, opportunities for future work using these circulating biomarkers are discussed.
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