Vascular smooth muscle phenotypic diversity and function

SA Fisher - Physiological genomics, 2010 - journals.physiology.org
… Of note, the cGK target the IP3 receptor-associated gated protein (IRAG = MRVI1) has not
been reported to be differentially expressed across smooth muscle tissues (86). …

Differential gene expression in vascular smooth muscle cells in primary atherosclerosis and in stent stenosis in humans

QJ Zhang, M Goddard, C Shanahan… - … , and vascular biology, 2002 - Am Heart Assoc
… sought to identify differentially expressed genes in human in … Target gene fragments were
cloned into a T7/SP6 promoter-… VSMCs exhibit a stable phenotype, intermediate between …

Smooth muscle cell heterogeneity: patterns of gene expression in vascular smooth muscle cells in vitro and in vivo

CM Shanahan, PL Weissberg - … , thrombosis, and vascular biology, 1998 - Am Heart Assoc
… of VSMC clones with apparently stable phenotypes in vitro. … gene expression that characterize
the phenotypic changes that occur in vivo and to determine the mechanisms that regulate

Myosin gene expression and cell phenotypes in vascular smooth muscle during development, in experimental models, and in vascular disease

S Sartore, A Chiavegato, R Franch… - … , and vascular biology, 1997 - Am Heart Assoc
… -MyHC isoforms are differentially expressed in SMCs during physiological and pathological
… from cloning of adult SM tissue display features in common with developing and “phenotype-…

Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery

S Li, YS Fan, LH Chow, C Van Den Diepstraten… - Circulation …, 2001 - Am Heart Assoc
Smooth muscle cells (SMCs) in the adult artery wall can manifest a diversity of phenotypes.
… Some SMC subsets have been shown to differentially respond to mitogenic factors, …

Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes

S Li, S Sims, Y Jiao, LH Chow, JG Pickering - Circulation research, 1999 - Am Heart Assoc
… capacity for bidirectional modulation of phenotype. However, this … cloning adult SMCs from
human internal thoracic artery. One clone, HITB5, expressed smooth muscle α-actin, smooth

Molecular control of vascular smooth muscle cell differentiation

GK Owens - Acta physiologica scandinavica, 1998 - Wiley Online Library
… Stretch affects phenotype and proliferation of vascular smooth muscle cells. MoL CellBiochem
… Molecular cloning and sequence analysis of smooth muscle calponin. J Bioi Chem 266, …

Regulation and characteristics of vascular smooth muscle cell phenotypic diversity

SSM Rensen, P Doevendans, G Van Eys - Netherlands Heart Journal, 2007 - Springer
… PDGF-B drove spindle-shaped SMC clones towards the rhomboid phenotype. Concomitantly,
… Many of these differentially expressed genes code for ECM or cytoskeletal proteins, and …

Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells.

CM Shanahan, PL Weissberg, JC Metcalfe - Circulation research, 1993 - Am Heart Assoc
… It is uncertain to what extent the phenotypic changes that occur in culture reflect the … in
transcript size for matrix Gla protein occurred in cultured vascular smooth muscle cells. Clones that …

… of fibroblast responses to transforming growth factor-β1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic …

RC Chambers, P Leoni, N Kaminski, GJ Laurent… - The American journal of …, 2003 - Elsevier
… used as a phenotypic marker of the … synthetic phenotype for vascular smooth muscle cells.
Of interest, maximal expression of most of these smooth-muscle cell phenotypic marker genes