Cognitive function of patients with adult moyamoya disease
Y Araki, Y Takagi, K Ueda, S Ubukata, J Ishida… - Journal of stroke and …, 2014 - Elsevier
Y Araki, Y Takagi, K Ueda, S Ubukata, J Ishida, T Funaki, T Kikuchi, JC Takahashi, T Murai…
Journal of stroke and cerebrovascular diseases, 2014•ElsevierBackground Neurocognitive impairment is one of several unsolved social issues faced by
patients with moyamoya disease. Although efforts have been made to investigate cognitive
function using neuropsychologic tasks, generalizability has been limited. Here, in a
preliminary study, we used structured neuropsychologic tasks to establish a standardized
neuropsychologic assessment for adult moyamoya patients with and without difficulty in
social independence. Methods Ten patients with neuroradiologically confirmed adult …
patients with moyamoya disease. Although efforts have been made to investigate cognitive
function using neuropsychologic tasks, generalizability has been limited. Here, in a
preliminary study, we used structured neuropsychologic tasks to establish a standardized
neuropsychologic assessment for adult moyamoya patients with and without difficulty in
social independence. Methods Ten patients with neuroradiologically confirmed adult …
Background
Neurocognitive impairment is one of several unsolved social issues faced by patients with moyamoya disease. Although efforts have been made to investigate cognitive function using neuropsychologic tasks, generalizability has been limited. Here, in a preliminary study, we used structured neuropsychologic tasks to establish a standardized neuropsychologic assessment for adult moyamoya patients with and without difficulty in social independence.
Methods
Ten patients with neuroradiologically confirmed adult moyamoya disease (3 male, 7 female) participated. Half of all subjects did not have difficulty with social independence (group 1) and the others had (group 2). Group differences were evaluated after basic cognitive abilities and frontal lobe function were tested.
Results
Although the mean age of group 1 was substantially higher than that of group 2, disease duration did not differ significantly between groups. Means scores for intelligence functions including all subtests for basic cognitive abilities were higher in group 1 compared with group 2. Scores from only 2 frontal lobe evaluation tasks (Trail Making Test B and Theory of Mind) were significantly different between groups.
Conclusions
This preliminary study provides a profile of neurocognitive dysfunction in adult patients with moyamoya disease using structured neuropsychologic tasks. A broad range of cognitive functions was disrupted particularly in the patients who had difficulty with social independence. To obtain stronger evidence regarding neurocognitive dysfunction in patients with moyamoya disease, a multicenter prospective study is essential.
Elsevier
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