Personnel files management is the fundamental work of human resources management in colleges, whose modernization and informatization construction should have a significant role in promoting human resources management in colleges. However, currently, the construction of personnel files informatization in colleges is only limited to personnel files digitalization and information electronization. Besides, only a simple sense of the personnel file information management system has been established, which cannot fundamentally solve the realistic difficulties in human resources management in colleges. In this paper, based on the authors' learning and practical experience, we firstly analyzed the necessity of the introduction of the big data technology into college files management, and then put forward the construction paths of college personnel files management informatization under the background of big data. Finally, the issues in application of big data in college files management were summarized.