Hot-melt extrusion (HME) has an esteemed place in the pharmaceutical industry with
significant applications and advancements spreading over 30 years of development.
Currently, the choice of matrix excipients is vast, expanding from all different kinds of
synthetic polymers to natural carriers. Non-biodegradable polymers are among the most
widely used excipients for long-acting controlled-release applications owing to their
robustness, prolonged and predictable drug-release rates, which result in high patient …