Purpose To determine the impact of patient age on the cost-effectiveness of endovascular
therapy (EVT) in addition to standard care (SC) in large-vessel-occlusion stroke for patients
aged 50 to 100 years in the United States. Materials and Methods A decision-analytic
Markov model was used to estimate direct and indirect lifetime costs and quality-adjusted life
years (QALYs). Age-dependent input parameters were obtained from the literature.
Deterministic and probabilistic sensitivity analysis for age at index stroke were used. The …

Though rarely considered in the clinical decision algorithm, issues of cost-effectiveness
assume critical importance for the sustainability of a widely used therapy that entails
considerable cost and has unproven benefit. Although current data are limited, we review
the studies that have demonstrated via modeling that endovascular stroke treatment may
generate significant future economic benefits, even if these treatments have a high price and
result in relatively small initial reductions in disability. We highlight important considerations …