Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas
Injury induces retinal Müller glia of cold-blooded, but not mammalian, vertebrates to
regenerate neurons. To identify gene regulatory networks that control neuronal
reprogramming in retinal glia, we comprehensively profiled injury-dependent changes in
gene expression and chromatin accessibility in Müller glia from zebrafish, chick and mice
using bulk RNA-Seq and ATAC-Seq, as well as single-cell RNA-Seq. Cross-species
integrative analysis of these data, together with functional validation, identified evolutionarily …
regenerate neurons. To identify gene regulatory networks that control neuronal
reprogramming in retinal glia, we comprehensively profiled injury-dependent changes in
gene expression and chromatin accessibility in Müller glia from zebrafish, chick and mice
using bulk RNA-Seq and ATAC-Seq, as well as single-cell RNA-Seq. Cross-species
integrative analysis of these data, together with functional validation, identified evolutionarily …
[PDF][PDF] Cross-species transcriptomic and epigenomic analysis reveals key regulators of
T Hoang, J Wang, P Boyd, F Wang, C Santiago - retina, 2017 - academia.edu
Injury induces retinal Müller glia of cold-blooded, but not mammalian, vertebrates to
generate neurons. To identify gene regulatory networks that control neuronal
reprogramming in retinal glia, we comprehensively profiled injury-dependent changes in
gene expression and chromatin conformation in Müller glia from zebrafish, chick and mice
using bulk RNA and ATAC-Seq, as well as single-cell RNA-Seq. Cross-species integrative
analysis of these data, together with functional validation of candidate genes, identified …
generate neurons. To identify gene regulatory networks that control neuronal
reprogramming in retinal glia, we comprehensively profiled injury-dependent changes in
gene expression and chromatin conformation in Müller glia from zebrafish, chick and mice
using bulk RNA and ATAC-Seq, as well as single-cell RNA-Seq. Cross-species integrative
analysis of these data, together with functional validation of candidate genes, identified …
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