Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality
Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are
oocyte-specific growth factors with central roles in mammalian reproduction, regulating
species-specific fecundity, ovarian follicular somatic cell differentiation, and oocyte quality. In
the human, GDF9 is produced in a latent form, the mechanism of activation being an open
question. Here, we produced a range of recombinant GDF9 and BMP15 variants, examined
their in silico and physical interactions and their effects on ovarian granulosa cells (GC) and …
oocyte-specific growth factors with central roles in mammalian reproduction, regulating
species-specific fecundity, ovarian follicular somatic cell differentiation, and oocyte quality. In
the human, GDF9 is produced in a latent form, the mechanism of activation being an open
question. Here, we produced a range of recombinant GDF9 and BMP15 variants, examined
their in silico and physical interactions and their effects on ovarian granulosa cells (GC) and …
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