Customized MethylC-capture sequencing to evaluate variation in the human sperm DNA methylome representative of altered folate metabolism
Background: The sperm DNA methylation landscape is unique and critical for offspring
health. If gamete-derived DNA methylation escapes reprograming in early embryos,
epigenetic defects in sperm may be transmitted to the next generation. Current techniques to
assess sperm DNA methylation show bias toward CpG-dense regions and do not target
areas of dynamic methylation, those predicted to be environmentally sensitive and tunable
regulatory elements. Objectives: Our goal was to assess variation in human sperm DNA …
health. If gamete-derived DNA methylation escapes reprograming in early embryos,
epigenetic defects in sperm may be transmitted to the next generation. Current techniques to
assess sperm DNA methylation show bias toward CpG-dense regions and do not target
areas of dynamic methylation, those predicted to be environmentally sensitive and tunable
regulatory elements. Objectives: Our goal was to assess variation in human sperm DNA …
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