… sepsis, the role of PAD2 remains unknown. Here, we report that PAD2 is engaged in sepsis
and sepsis… mouse models of sepsis. Pad2 deficiency decreased neutrophil extracellular trap (…

… It is now widely accepted that sepsis occurs in two concurrent … As such, sepsis remains one
of the leading causes of … Lack of specific treatments available for sepsis is mostly due to our …

… when damage-associated molecular patterns (DAMPS) such as the high mobility group …
the DAMPs and PAMPs but has the potential to become excessively activated in sepsis and …

… NETs have very important roles in the pathogenesis of sepsis. NETs can capture pathogens
… components cannot be controlled, they can cause serious and irreversible harm to sepsis …

… formation, is involved in sepsis. Unlike apoptosis, pyroptosis is a … Related studies have shown
that in sepsis, moderate … regulatory mechanisms of pyroptosis in sepsis and SAOD. As our …

… leukocytes expelled DAMPs and accelerated further inflammation during sepsis. In this
study, AT and rTM were revealed to inhibit leukocyte necrosis, reduce the circulating DAMPs, …

… sepsis both in humans and mice with polymicrobial sepsis results in robust activation of
complement. Major complement activation products involved in sepsis … of C5a during sepsis also …

… on NETs, which improves the development of sepsis by preventing the release of pro-inflammatory
factors[8]. Excessive release of NETs … -associated molecular patterns (DAMPs), can …

… In conclusion, our study demonstrates that DAMPs released during liver I/R result in NET
formation through TLR-dependent pathways and subsequently exacerbate liver I/R. We …

… of DAMPs in infections. Because of their often critical role in cellular functions many DAMPs
… by LPS injection or bacterial induced sepsis potentially because calprotectin can drive …