Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy
T Yang, GM Brittenham, WQ Dong, MN Levy… - Journal of Laboratory …, 2003 - Elsevier
To evaluate the effects of the iron chelator deferoxamine on the functional and structural
manifestations of iron-induced cardiac dysfunction, we measured cardiac power, left
ventricular systolic, and diastolic function as (dP/dt) max and (dP/dt) min, respectively, and
left ventricular and septal wall thickness in isolated heart preparations derived from the
Mongolian gerbil model of iron overload. We induced iron overload with weekly
subcutaneous injections of iron dextran (800 mg/kg/wk); deferoxamine (DFO; 100 mg/kg) …
manifestations of iron-induced cardiac dysfunction, we measured cardiac power, left
ventricular systolic, and diastolic function as (dP/dt) max and (dP/dt) min, respectively, and
left ventricular and septal wall thickness in isolated heart preparations derived from the
Mongolian gerbil model of iron overload. We induced iron overload with weekly
subcutaneous injections of iron dextran (800 mg/kg/wk); deferoxamine (DFO; 100 mg/kg) …
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