Dengue virus subverts host innate immunity by targeting adaptor protein MAVS
Z He, X Zhu, W Wen, J Yuan, Y Hu, J Chen… - Journal of …, 2016 - Am Soc Microbiol
Dengue virus (DENV) is the most common mosquito-borne virus infecting humans and is
currently a serious global health challenge. To establish infection in its host cells, DENV
must subvert the production and/or antiviral effects of interferon (IFN). The aim of this study
was to understand the mechanisms by which DENV suppresses IFN production. We
determined that DENV NS4A interacts with mitochondrial antiviral signaling protein (MAVS),
which was previously found to activate NF-κB and IFN regulatory factor 3 (IRF3), thus …
currently a serious global health challenge. To establish infection in its host cells, DENV
must subvert the production and/or antiviral effects of interferon (IFN). The aim of this study
was to understand the mechanisms by which DENV suppresses IFN production. We
determined that DENV NS4A interacts with mitochondrial antiviral signaling protein (MAVS),
which was previously found to activate NF-κB and IFN regulatory factor 3 (IRF3), thus …
Dengue virus subverts host innate immunity by targeting adaptor protein MAVS.
HZJ He ZhenJian, ZX Zhu Xun, WWT Wen WeiTao… - 2016 - cabidigitallibrary.org
Dengue virus (DENV) is the most common mosquito-borne virus infecting humans and is
currently a serious global health challenge. To establish infection in its host cells, DENV
must subvert the production and/or antiviral effects of interferon (IFN). The aim of this study
was to understand the mechanisms by which DENV suppresses IFN production. We
determined that DENV NS4A interacts with mitochondrial antiviral signaling protein (MAVS),
which was previously found to activate NF-κB and IFN regulatory factor 3 (IRF3), thus …
currently a serious global health challenge. To establish infection in its host cells, DENV
must subvert the production and/or antiviral effects of interferon (IFN). The aim of this study
was to understand the mechanisms by which DENV suppresses IFN production. We
determined that DENV NS4A interacts with mitochondrial antiviral signaling protein (MAVS),
which was previously found to activate NF-κB and IFN regulatory factor 3 (IRF3), thus …
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