Most epidemiological and experimental studies have focused on maternal influences on
offspring's health. The impact of maternal undernutrition, overnutrition, hypoxia, and stress is
linked to adverse offspring outcomes across a range of systems including cardiometabolic,
respiratory, endocrine, and reproduction among others. During the past decade, it has
become evident that paternal environmental factors are also linked to the development of
diseases in offspring. In this article, we aim to outline the current understanding of the impact …

The concept of the early life developmental origins of health and disease (DOHaD) in adults
has stimulated a new approach to understanding disease trajectories, with major public
health implications. Indeed, the principle of the'lifecourse of disease'now influences health
policies internationally. Environmental influences during pregnancy and early life that affect
lifelong health are well documented, but there is a new focus on the preconception period
and the significance of paternal health on the fetus. This fully revised second edition …