Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.
Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are
methylated in sperm DNA and unmodified in mature oocytes, indicating that the parental
genomes have differential methylation profiles. These differences, however, are erased by a
series of early embryonic demethylation and postblastula remodification events, which serve
to reestablish the basic adult methylation pattern prior to organogenesis. During …
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are
methylated in sperm DNA and unmodified in mature oocytes, indicating that the parental
genomes have differential methylation profiles. These differences, however, are erased by a
series of early embryonic demethylation and postblastula remodification events, which serve
to reestablish the basic adult methylation pattern prior to organogenesis. During …
[PDF][PDF] Developmental pattern of gene-specific DNA methylation in the
T Kafri, M Ariel, M Brandeis - researchgate.net
Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are
methylated in sperm DNA and unmodified in mature oocytes, indicating that the parental
genomes have differential methylation profiles. These differences, however, are erased by a
series of early embryonic demethylation and postblastula remodification events, which serve
to reestablish the basic adult methylation pattern prior to organogenesis. During …
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are
methylated in sperm DNA and unmodified in mature oocytes, indicating that the parental
genomes have differential methylation profiles. These differences, however, are erased by a
series of early embryonic demethylation and postblastula remodification events, which serve
to reestablish the basic adult methylation pattern prior to organogenesis. During …