EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that
are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by
binding complementary regions in messenger RNAs, are broadly implicated in cancer.
Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated
transcriptional program of microRNAs and transcription factors. The earliest event involved a
decrease in the abundance of a subset of 23 microRNAs. This step permitted rapid induction …
are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by
binding complementary regions in messenger RNAs, are broadly implicated in cancer.
Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated
transcriptional program of microRNAs and transcription factors. The earliest event involved a
decrease in the abundance of a subset of 23 microRNAs. This step permitted rapid induction …
[PDF][PDF] EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that
are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by
binding complementary regions in messenger RNAs, are broadly implicated in cancer.
Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated
transcriptional program of microRNAs and transcription factors. The earliest event involved a
decrease in the abundance of a subset of 23 microRNAs. This step permitted rapid induction …
are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by
binding complementary regions in messenger RNAs, are broadly implicated in cancer.
Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated
transcriptional program of microRNAs and transcription factors. The earliest event involved a
decrease in the abundance of a subset of 23 microRNAs. This step permitted rapid induction …
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