Importance Alkaline free-base nicotine is bitter and a respiratory irritant. High-nicotine
electronic cigarette (e-cigarette) products contain acid additives that change nicotine from a
free-base to a protonated salt chemical form, which could improve the sensory experience of
vaping, particularly among never smokers unaccustomed to inhaling free-base nicotine.
Objective To determine whether exposure to e-cigarettes with salt vs free-base nicotine
formulations improves the appeal and sensory experience of vaping e-cigarettes and …