Effect of graded O2 challenge on vascular and metabolic parameters
F Xu, P Liu, H Lu - Proc. Int. Soc. Magn. Reson. Med, 2011 - archive.ismrm.org
Calibrated fMRI relies on an iso-CMRO2 challenge to obtain the calibration factor. O2
challenge has been proposed to be a potential method for the calibration experiment.
However, the assumption that O2 challenge is iso-CMRO2 has not been validated. The
present study will investigate whether physiologic manipulation of O2 content in the arterial
blood will change brain metabolism. We used a recently developed TRUST MRI technique
to monitor the subjects CMRO2 while altering the O2 concentration in the inspired air. Our …
challenge has been proposed to be a potential method for the calibration experiment.
However, the assumption that O2 challenge is iso-CMRO2 has not been validated. The
present study will investigate whether physiologic manipulation of O2 content in the arterial
blood will change brain metabolism. We used a recently developed TRUST MRI technique
to monitor the subjects CMRO2 while altering the O2 concentration in the inspired air. Our …
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