Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial
PA Poole-Wilson, J Lubsen, BA Kirwan, FJ van Dalen… - The Lancet, 2004 - thelancet.com
Background Calcium antagonists are widely prescribed for angina pectoris but their effect on
clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist
nifedipine on long-term outcome in patients with stable angina pectoris. Methods We
randomly assigned 3825 patients with treated stable symptomatic coronary disease to
double-blind addition of nifedipine GITS (gastrointestinal therapeutic system) 60 mg once
daily and 3840 to placebo. The primary endpoint was the combination of death, acute …
clinical outcome is controversial. We aimed to investigate the effect of the calcium antagonist
nifedipine on long-term outcome in patients with stable angina pectoris. Methods We
randomly assigned 3825 patients with treated stable symptomatic coronary disease to
double-blind addition of nifedipine GITS (gastrointestinal therapeutic system) 60 mg once
daily and 3840 to placebo. The primary endpoint was the combination of death, acute …
Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension: the ACTION trial
J Lubsen, G Wagener, BA Kirwan… - Journal of …, 2005 - journals.lww.com
Objective To examine the effects of nifedipine GITS on clinical outcome in patients with
concurrent stable angina and hypertension. Methods Data from the double-blind placebo-
controlled ACTION trial was stratified for hypertension (blood pressure≥ 140/90 mmHg), at
baseline. Results A total of 52% of 7665 ACTION patients were hypertensive. Some 80%
were on a β blocker; hypertensives were more often treated with other blood pressure-
lowering drugs. Mean baseline blood pressure was 122/74 mmHg among normotensives …
concurrent stable angina and hypertension. Methods Data from the double-blind placebo-
controlled ACTION trial was stratified for hypertension (blood pressure≥ 140/90 mmHg), at
baseline. Results A total of 52% of 7665 ACTION patients were hypertensive. Some 80%
were on a β blocker; hypertensives were more often treated with other blood pressure-
lowering drugs. Mean baseline blood pressure was 122/74 mmHg among normotensives …
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