Efficiency of endovenous versus arterial administration of mesenchymal stem cells for ischemia-reperfusion–induced renal dysfunction in rats

W Zhuo, L Liao, Y Fu, T Xu, W Wu, S Yang… - Transplantation …, 2013 - Elsevier
BACKGROUND: Ischemia followed by reperfusion leads to acute renal failure in both native
kidneys and a renal allograft. Our previous study found that transplantation of mesenchymal
stem cells (MSCs) ameliorated ischemia-reperfusion (I/R)-induced kidney dysfunction by
increasing the activities of antioxidant enzymes. The purpose of this study was to evaluate
whether intra-arterial versus intravenous administration was more effective. METHODS:
Renal ischemia was induced by clamping the right renal vessels for 60 minutes after …
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