Efficient and facile 'on-solvent' multicomponent synthesis of medicinally privileged pyrano[3,2-c]pyridine scaffold
MN Elinson, FV Ryzhkov, AN Vereshchagin… - Research on Chemical …, 2018 - Springer
MN Elinson, FV Ryzhkov, AN Vereshchagin, AS Goloveshkin, IS Bushmarinov, MP Egorov
Research on Chemical Intermediates, 2018•SpringerThe new type of 'on-solvent'multicomponent reaction was found: transformation of
benzaldehydes, malononitrile and 4–hydroxy-6-methylpyridin-2 (1 H)-one in the presence of
sodium acetate as catalyst in a small amount of ethanol results in formation of substituted 2-
amino-7-methyl-5-oxo-4-phenyl-5, 6-dihydro-4 H-pyrano [3, 2-c] pyridine-3-carbonitriles in
excellent 92–99% yields. This novel 'one-pot'process opens an efficient and convenient way
to functionalize pyrano [3, 2-c] pyridine systems, which are promising compounds for …
benzaldehydes, malononitrile and 4–hydroxy-6-methylpyridin-2 (1 H)-one in the presence of
sodium acetate as catalyst in a small amount of ethanol results in formation of substituted 2-
amino-7-methyl-5-oxo-4-phenyl-5, 6-dihydro-4 H-pyrano [3, 2-c] pyridine-3-carbonitriles in
excellent 92–99% yields. This novel 'one-pot'process opens an efficient and convenient way
to functionalize pyrano [3, 2-c] pyridine systems, which are promising compounds for …
Abstract
The new type of ‘on-solvent’ multicomponent reaction was found: transformation of benzaldehydes, malononitrile and 4–hydroxy-6-methylpyridin-2(1H)-one in the presence of sodium acetate as catalyst in a small amount of ethanol results in formation of substituted 2-amino-7-methyl-5-oxo-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles in excellent 92–99% yields. This novel ‘one-pot’ process opens an efficient and convenient way to functionalize pyrano[3,2-c]pyridine systems, which are promising compounds for different biomedical applications.
Springer
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