Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans.
Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as
a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its
translocation into the grain and reduce the amount of As entering the food chain. We
developed transgenic rice plants expressing two different vacuolar As sequestration genes,
Sc YCF 1 and Os ABCC 1, under the control of the RC c3 promoter in the root cortical and …

Arsenic (As) is a poisonous element that causes severe skin lesions and cancer in humans.
Rice (Oryza sativa L.) is a major dietary source of As in humans who consume this cereal as
a staple food. We hypothesized that increasing As vacuolar sequestration would inhibit its
translocation into the grain and reduce the amount of As entering the food chain. We
developed transgenic rice plants expressing two different vacuolar As sequestration genes,
ScYCF1 and OsABCC1, under the control of the RCc3 promoter in the root cortical and …