Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
A Huether, M Höpfner, AP Sutter, D Schuppan… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancer-
related causes of death worldwide. In light of the very poor 5-year-survival new therapeutic
approaches are urgently needed. Recently, evidence has been accumulated that the
epidermal growth factor receptor (EGFR) is a promising target for cancer therapy. Several
reports indicate that EGFRs are expressed frequently in HCC, most likely contributing to the
aggressive growth characteristics of these tumors. METHODS: Erlotinib, an inhibitor of EGFR …
related causes of death worldwide. In light of the very poor 5-year-survival new therapeutic
approaches are urgently needed. Recently, evidence has been accumulated that the
epidermal growth factor receptor (EGFR) is a promising target for cancer therapy. Several
reports indicate that EGFRs are expressed frequently in HCC, most likely contributing to the
aggressive growth characteristics of these tumors. METHODS: Erlotinib, an inhibitor of EGFR …
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