Quantitative ultrasound techniques using backscattered echoes have had limited success in
vivo due to the frequency-dependent attenuation along the entire propagation path masking
the frequency dependence of the backscatter. Herein, total attenuation and scatterer size are
estimated simultaneously by an analysis of the in vivo backscattered power spectrum using
two approaches. The simulations used to evaluate the two approaches used frequencies
between 4 and 11 MHz with an effective scatterer radius of 25 μm. The first approach was …