Background With apparent declines in malaria worldwide during the last decade and more
widespread use of malaria rapid diagnostic tests, healthcare workers in low-resource areas
face a growing proportion of febrile patients without malaria. We sought to describe current
knowledge and identify information gaps of the etiology severe febrile illness in low-and
middle-income countries. Methods and Findings We conducted a systematic review of
studies conducted in low-and-middle income countries 1980–2013 that prospectively …

Background: With apparent declines in malaria worldwide during the last decade and more
widespread use of malaria rapid diagnostic tests, healthcare workers in low-resource areas
face a growing proportion of febrile patients without malaria. We sought to describe current
knowledge and identify information gaps of the etiology severe febrile illness in low-and
middle-income countries. Methods and Findings: We conducted a systematic review of
studies conducted in low-and-middle income countries 1980-2013 that prospectively …