Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain
FL Wormley Jr, GM Cox, JR Perfect - Microbial pathogenesis, 2005 - Elsevier
Cryptococcus neoformans is an opportunistic fungal pathogen that threatens individuals with
impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines
available to prevent cryptococcal infections and conventional anti-fungal drug therapy does
not induce host immune reactivity and thus cannot efficiently resolve C. neoformans
infections in immunocompromised individuals. The present study was designed to
characterize pulmonary immune responses following infection with an avirulent temperature …
impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines
available to prevent cryptococcal infections and conventional anti-fungal drug therapy does
not induce host immune reactivity and thus cannot efficiently resolve C. neoformans
infections in immunocompromised individuals. The present study was designed to
characterize pulmonary immune responses following infection with an avirulent temperature …
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