Exploring the association between polycyclic aromatic hydrocarbons and diabetes among adults in the United States
S Stallings-Smith, A Mease, TM Johnson… - Environmental …, 2018 - Elsevier
Environmental research, 2018•Elsevier
Objective To explore the association between polycyclic aromatic hydrocarbons (PAHs) and
diabetes and to determine whether effects are heterogeneous when examined by body
mass index (BMI). Methods Cross-sectional data from 8664 participants were analyzed from
the National Health and Nutrition Examination Survey for years 2005–2014. Multivariable
logistic regression was used to explore the association between urinary biomarkers of PAHs
and diabetes. All models were adjusted for age, sex, race, poverty-income ratio, and serum …
diabetes and to determine whether effects are heterogeneous when examined by body
mass index (BMI). Methods Cross-sectional data from 8664 participants were analyzed from
the National Health and Nutrition Examination Survey for years 2005–2014. Multivariable
logistic regression was used to explore the association between urinary biomarkers of PAHs
and diabetes. All models were adjusted for age, sex, race, poverty-income ratio, and serum …
Objective
To explore the association between polycyclic aromatic hydrocarbons (PAHs) and diabetes and to determine whether effects are heterogeneous when examined by body mass index (BMI).
Methods
Cross-sectional data from 8664 participants were analyzed from the National Health and Nutrition Examination Survey for years 2005–2014. Multivariable logistic regression was used to explore the association between urinary biomarkers of PAHs and diabetes. All models were adjusted for age, sex, race, poverty-income ratio, and serum cotinine.
Results
When compared with the lowest quintiles of exposure, the highest quintiles of exposure to 2-hydroxynaphthalene, 2-hydroxyfluorene, 9-hydroxyfluorene, 2-hydroxyphenanthrene, and a summed variable of all low molecular weight PAHs (aOR = 1.73; 95% CI: 1.17–2.55) showed a positive association with diabetes. Stratified analyses by BMI indicated that the positive association between PAHs and diabetes was found among both normal weight and obese participants.
Conclusions
High levels of exposure to PAHs are positively associated with diabetes in the U.S. general population and these effects are modified by BMI. These findings suggest the importance of strong environmental regulation of PAHs to protect population health.
Elsevier
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