Long, short and medium chain fatty acids are covalently attached to hundreds of proteins.
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate
intracellular trafficking, subcellular localization, protein-protein and protein-lipid interactions.
Myristate and palmitate represent the most common fatty acid modifying groups. New
insights into how fatty acylation reactions are catalyzed, and how fatty acylation regulates
protein structure and function continue to emerge. Myristate is typically linked to an N …