Fluorine biocatalysis
L Wu, F Maglangit, H Deng - Current Opinion in Chemical Biology, 2020 - Elsevier
… to produce novel fluorinated commodities. Here, we review the fluorinase biotechnology
and fluorine biocatalysts that incorporate fluorine motifs to generate fluorinated molecules, and …
and fluorine biocatalysts that incorporate fluorine motifs to generate fluorinated molecules, and …
A nonconventional archaeal fluorinase identified by in silico mining for enhanced fluorine biocatalysis
Fluorinases, the only enzymes known to catalyze the transfer of fluorine to an organic molecule,
are essential catalysts for the biological synthesis of valuable organofluorines. However, …
are essential catalysts for the biological synthesis of valuable organofluorines. However, …
In vivo fluorine biocatalysis: Six enzymes in search of a cell factory
… interesting building-block for biocatalysis as it can be activated … These six enzymes are key
to developing fluorine biocatalysis; … platform for biohalogenation via whole-cell biocatalysis …
to developing fluorine biocatalysis; … platform for biohalogenation via whole-cell biocatalysis …
Evolution of fluorinated enzymes: An emerging trend for biocatalyst stabilization
H Biava, N Budisa - Engineering in Life Sciences, 2014 - Wiley Online Library
… that introduction of fluorinated amino acids constitute an … stable biocatalysts for industrial
applications. Despite these being preliminary results and none of these fluorinated biocatalysts …
applications. Despite these being preliminary results and none of these fluorinated biocatalysts …
Enzymatic synthesis of mono-and trifluorinated alanine enantiomers expands the scope of fluorine biocatalysis
M Nieto-Domínguez, A Sako… - Communications …, 2024 - nature.com
… Fluorinated amino acids serve as an entry point for establishing new-to-Nature chemistries
… enzymatic synthesis of fluorinated alanine enantiomers to expand fluorine biocatalysis. The …
… enzymatic synthesis of fluorinated alanine enantiomers to expand fluorine biocatalysis. The …
Enzyme-catalyzed C–F bond formation and cleavage
W Tong, Q Huang, M Li, J Wang - Bioresources and Bioprocessing, 2019 - Springer
… Biocatalytic oxidation and reduction defluorination by micro-organisms containing organic
fluorine compounds have been reviewed to analyze their ability to handle such specific …
fluorine compounds have been reviewed to analyze their ability to handle such specific …
Biocatalytic carbon–hydrogen and carbon–fluorine bond cleavage through hydroxylation promoted by a histidyl-ligated heme enzyme
… oxygenation at C3 concomitant with a carbon–fluorine bond cleavage to yield DOPA and
fluoride. … Thus, this finding reveals a significant potential of biocatalysis in C–H/C–X bond (X = …
fluoride. … Thus, this finding reveals a significant potential of biocatalysis in C–H/C–X bond (X = …
Enzymatic synthesis of fluorinated compounds
X Cheng, L Ma - Applied Microbiology and Biotechnology, 2021 - Springer
… As such, reductive aminase provides a sustainable and highly economical biocatalysis
toolbox, which can synthesize fluorinated chiral amines and fluorinated chiral alcohols from …
toolbox, which can synthesize fluorinated chiral amines and fluorinated chiral alcohols from …
Biocatalytic enantioselective C(sp3)–H fluorination enabled by directed evolution of non-haem iron enzymes
… Next, to elucidate the reactivities of the unnatural fluorine atom transfer and fluorine rebound
steps, we performed DFT calculations of the reaction energy profile of this biocatalytic C–H …
steps, we performed DFT calculations of the reaction energy profile of this biocatalytic C–H …
Biocatalytic Asymmetric Construction of Secondary and Tertiary Fluorides from β‐Fluoro‐α‐Ketoacids
J Fang, LE Turner, MCY Chang - Angewandte Chemie, 2022 - Wiley Online Library
… Biocatalysis offers a complementary approach with the potential for exceptional selectivity
… , interfacing biocatalysis with fluorine chemistry must contend with the rarity of fluorine in the …
… , interfacing biocatalysis with fluorine chemistry must contend with the rarity of fluorine in the …