From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are
implicated in major metabolic and inflammatory regulations with far-reaching medical
consequences, as well as in important processes controlling cellular fate. Throughout this
review, we focus on the cellular functions of these receptors. The molecular mechanisms
through which PPARs regulate transcription are thoroughly addressed with particular …
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are
implicated in major metabolic and inflammatory regulations with far-reaching medical
consequences, as well as in important processes controlling cellular fate. Throughout this
review, we focus on the cellular functions of these receptors. The molecular mechanisms
through which PPARs regulate transcription are thoroughly addressed with particular …
以上显示的是最相近的搜索结果。 查看全部搜索结果