GAL3 receptor knockout mice exhibit an alcohol‐preferring phenotype
SG Genders, KJ Scheller, EJ Jaehne… - Addiction …, 2019 - Wiley Online Library
Galanin is a neuropeptide which mediates its effects via three G‐protein coupled receptors
(GAL1–3). Administration of a GAL3 antagonist reduces alcohol self‐administration in
animal models while allelic variation in the GAL3 gene has been associated with an
increased risk of alcohol use disorders in diverse human populations. Based on the
association of GAL3 with alcoholism, we sought to characterize drug‐seeking behavior in
GAL3‐deficient mice for the first time. In the two‐bottle free choice paradigm, GAL3‐KO mice …
(GAL1–3). Administration of a GAL3 antagonist reduces alcohol self‐administration in
animal models while allelic variation in the GAL3 gene has been associated with an
increased risk of alcohol use disorders in diverse human populations. Based on the
association of GAL3 with alcoholism, we sought to characterize drug‐seeking behavior in
GAL3‐deficient mice for the first time. In the two‐bottle free choice paradigm, GAL3‐KO mice …
[PDF][PDF] GAL3 receptor knockout mice exhibit an alcohol-preferring phenotype Shannyn G. Gendersa, Karlene J. Schellera, Emily J. Jaehneb, Bradley J. Turnerc …
E Djouma - minerva-access.unimelb.edu.au
Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors
(GAL1-3). Administration of a GAL3 antagonist reduces alcohol self-administration in animal
models while allelic variation in the GAL3 gene has been associated with an increased risk
of alcohol use disorders in diverse human populations. Based on the association of GAL3
with alcoholism, we sought to characterise drug-seeking behavior in GAL3-deficient mice for
the first time. In the two-bottle free choice paradigm, GAL3-KO mice consistently showed a …
(GAL1-3). Administration of a GAL3 antagonist reduces alcohol self-administration in animal
models while allelic variation in the GAL3 gene has been associated with an increased risk
of alcohol use disorders in diverse human populations. Based on the association of GAL3
with alcoholism, we sought to characterise drug-seeking behavior in GAL3-deficient mice for
the first time. In the two-bottle free choice paradigm, GAL3-KO mice consistently showed a …
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