The ability of galantamine (Reminyl®) to inhibit the aggregation and toxicity of the β-amyloid
peptide (Aβ) was investigated. Galantamine showed concentration-dependent inhibition of
aggregation of both Aβ 1-40 and Aβ 1-42, as determined by an ELISA method. Electron
microscope studies of Aβ 1-40 incubated in the presence of galantamine revealed fibrils that
were disordered and clumped in appearance. MTT and lactate dehydrogenase assays,
employing SH-SY5Y human neuroblastoma cells, showed that galantamine reduced the …

The ability of galantamine (Reminyl®) to inhibit the aggregation and toxicity of the β-^ amy
loid peptide (Aβ) was investigated. Galantamine showed concentration-^ dep endent
inhibition of aggregation of both Aβ 1-^ 40 and Aβ 1-^ 42, as determined by an ELISA
method. Electron microscope studies of Aβ 1-^ 40 incubated in the presence of galantamine
revealed fibrils that were disordered and clumped in appearance. MTT and lactate
dehydrogenase assays, employing S H-^ SY5Y human neuroblastoma cells, showed that …