Gallotannin ameliorates the development of streptozotocin‐induced diabetic nephropathy by preventing the activation of PARP
PG Chandak, AB Gaikwad… - Phytotherapy Research: An …, 2009 - Wiley Online Library
Abstract Poly (ADP‐ribose) polymerase (PARP) is known to be activated under conditions of
oxidative stress and/or radiation exposure. The role of this enzyme has been well
demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by
specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy
by reduction in oxidative stress induced apoptosis. This study shows for the first time the role
of poly (ADP‐ribose) glycohydrolase (PARG) inhibitors as an alternative approach for …
oxidative stress and/or radiation exposure. The role of this enzyme has been well
demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by
specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy
by reduction in oxidative stress induced apoptosis. This study shows for the first time the role
of poly (ADP‐ribose) glycohydrolase (PARG) inhibitors as an alternative approach for …
Gallotannin ameliorates the development of streptozotocin‐induced diabetic nephropathy by preventing the activation of PARP
AB Gaikwad - 2008 - dspace.bits-pilani.ac.in
Poly (ADP-ribose) polymerase (PARP) is known to be activated under conditions of
oxidative stress and/or radiation exposure. The role of this enzyme has been well
demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by
specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy
by reduction in oxidative stress induced apoptosis. This study shows for the first time the role
of poly (ADP-ribose) glycohydrolase (PARG) inhibitors as an alternative approach for …
oxidative stress and/or radiation exposure. The role of this enzyme has been well
demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by
specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy
by reduction in oxidative stress induced apoptosis. This study shows for the first time the role
of poly (ADP-ribose) glycohydrolase (PARG) inhibitors as an alternative approach for …
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