Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
I Hatada, S Morita, M Kimura, T Horii… - Journal of human …, 2008 - nature.com
Journal of human genetics, 2008•nature.com
Epigenetic regulation including DNA methylation plays an important role in several
differentiation processes. We profiled global DNA methylation in the neural differentiation of
P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a
genome-wide demethylation of genes. This suggests demethylation rather than methylation
is important in neural differentiation.
differentiation processes. We profiled global DNA methylation in the neural differentiation of
P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a
genome-wide demethylation of genes. This suggests demethylation rather than methylation
is important in neural differentiation.
Abstract
Epigenetic regulation including DNA methylation plays an important role in several differentiation processes. We profiled global DNA methylation in the neural differentiation of P19 embryonic carcinoma cells using a microarray-based method called MIAMI. We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation.
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