Three-dimensional genome architecture: players and mechanisms

A Pombo, N Dillon - Nature reviews Molecular cell biology, 2015 - nature.com
genome-wide data that provide deep insights into the formation of chromatin interactions, and
into … The nuclear envelope is a membrane bilayer, made up of the inner and outer nuclear …

Molecular basis of mechanotransduction in living cells

OP Hamill, B Martinac - Physiological reviews, 2001 - journals.physiology.org
bilayer and cell membrane mechanics, their specific effects have been little studied. … to
analyze possible underlying molecular mechanisms in extremely well-defined simple systems. …

Functional genomics to uncover drug mechanism of action

SMB Nijman - Nature chemical biology, 2015 - nature.com
… as it directly relates to drug action in its cellular or organismal context. Particularly in … provides
compelling insights into drug mechanism of action. However, until recently genetic tools to …

Polymer genomics: an insight into pharmacology and toxicology of nanomedicines

AV Kabanov - Advanced drug delivery reviews, 2006 - Elsevier
… amount of the neutral lipid molecules in the opposite direction from the outer to inner
membrane leaflet, which enables the liposome membrane to keep its bilayer structure intact. The …

Molecular mechanics of the mycobacterial cell wall: from horizontal layers to vertical scaffolds

BA Dmitriev, S Ehlers, ET Rietschel… - International journal of …, 2000 - Elsevier
cell wall constituents are still missing. Nevertheless, we feel confident that our approach of
'molecular mechanics' may … data concerning the architecture of the mycobacterial cell wall. …

[HTML][HTML] Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights

B Zhang, P Wei, Z Zhou, T Wei - Advanced drug delivery reviews, 2016 - Elsevier
… papillomavirus (HPV) genome also show increased uptake … at a distance of 0.5 nm above
the bilayer. The results of the … new mechanistic insight into how the cellular internalization of …

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers

RC Stone, O Stojadinovic, AM Rosa… - Science translational …, 2017 - science.org
… This study provides mechanistic insight into how the acute … The bioengineered bilayered
living cellular construct (BLCC) … genomic and molecular end points that can be incorporated …

Unveiling molecular mechanisms of bacterial surface proteins: Streptococcus pneumoniae as a model organism for structural studies

MJ Jedrzejas - Cellular and molecular life sciences, 2007 - Springer
… through a covalent linkage to the cytoplasmic bilayer lipids. … , generated by such genomic
sequence-driven studies. The … new insight into the structure and function of this molecule and …

Fundamentals on the molecular mechanism of action of antimicrobial peptides

JAF Corrêa, AG Evangelista, T de Melo Nazareth… - Materialia, 2019 - Elsevier
… of mechanisms of action, as well as mechanisms of … genetic manipulation of strains. Such
data is vital, especially … density of AMPs – that the bilayer is destabilized by fluidity changes and …

[图书][B] Computational systems biology: From molecular mechanisms to disease

A Kriete, R Eils - 2013 - books.google.com
… a turning point was reached at the molecular basis of life. The frontiers of research … genomics
becoming the first in a growing series of “-omics” disciplines. Although functional genomics