Ghrelin increases food intake in obese as well as lean subjects

MR Druce, AM Wren, AJ Park, JE Milton… - International journal of …, 2005 - nature.com
MR Druce, AM Wren, AJ Park, JE Milton, M Patterson, G Frost, MA Ghatei, C Small…
International journal of obesity, 2005•nature.com
OBJECTIVE: To investigate whether effects on food intake are seen in obese subjects
receiving exogenous administration of ghrelin. DESIGN: Randomised, double-blind,
placebo-controlled study of intravenous ghrelin at doses 1 pmol/kg/min and 5 pmol/kg/min.
SUBJECTS: In all, 12 healthy lean subjects (mean body mass index (BMI) 20.5±0.17 kg/m 2)
and 12 healthy overweight and obese subjects (mean BMI 31.9±1.02 kg/m 2).
MEASUREMENTS: Food intake, appetite and palatability of food, ghrelin and other obesity …
Abstract
OBJECTIVE:
To investigate whether effects on food intake are seen in obese subjects receiving exogenous administration of ghrelin.
DESIGN:
Randomised, double-blind, placebo-controlled study of intravenous ghrelin at doses 1 pmol/kg/min and 5 pmol/kg/min.
SUBJECTS:
In all, 12 healthy lean subjects (mean body mass index (BMI) 20.5±0.17 kg/m 2) and 12 healthy overweight and obese subjects (mean BMI 31.9±1.02 kg/m 2).
MEASUREMENTS:
Food intake, appetite and palatability of food, ghrelin and other obesity-related hormones, growth hormone.
RESULTS:
Low-dose infusion of ghrelin increased ad libitum energy intake at a buffet meal in the obese group only (mean increase 36.6±9.4%, P< 0.01.) High-dose ghrelin infusion increased energy intake in both groups (mean increase 20.1±10.6% in the lean and 70.1±15.5% in the obese, P< 0.01 in both cases.) Ghrelin infusion increased palatability of food in the obese group.
CONCLUSION:
Ghrelin increases food intake in obese as well as lean subjects. Obese people are sensitive to the appetite-stimulating effects of ghrelin and inhibition of circulating ghrelin may be a useful therapeutic target in the treatment of obesity.
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