Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as …
MD Thompson, Y Mei, RM Weisbrod, M Silver… - Journal of Biological …, 2014 - ASBMB
The sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) is key to Ca 2+ homeostasis and
is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that
stimulate Ca 2+ uptake activity and endothelial cell angiogenic responses in vitro. We found
that mouse hind limb muscle ischemia induced S-glutathione adducts on SERCA in both
whole muscle tissue and endothelial cells. To determine the role of S-glutathiolation, we
used a SERCA 2 C674S heterozygote knock-in (SKI) mouse lacking half the key thiol …
is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that
stimulate Ca 2+ uptake activity and endothelial cell angiogenic responses in vitro. We found
that mouse hind limb muscle ischemia induced S-glutathione adducts on SERCA in both
whole muscle tissue and endothelial cells. To determine the role of S-glutathiolation, we
used a SERCA 2 C674S heterozygote knock-in (SKI) mouse lacking half the key thiol …
以上显示的是最相近的搜索结果。 查看全部搜索结果