Glycopeptide-induced neutropenia: cross-reactivity between vancomycin and teicoplanin
SH Hsiao, CM Chang, JC Tsai, CY Lin… - Annals of …, 2007 - journals.sagepub.com
SH Hsiao, CM Chang, JC Tsai, CY Lin, LH Liao, WL Lin, TJ Wu
Annals of Pharmacotherapy, 2007•journals.sagepub.comObjective: To report teicoplanin-related neutropenia that developed after an episode of
neutropenia induced by vancomycin therapy. Case Summary: A 57-year-old female suffered
from osteomyelitis of the left humerus, with a white blood cell (WBC) count of 2.8× 103/mm3
and absolute neutrophil count (ANC) of 0.28× 103/mm3, occurring after 24 days of
vancomycin therapy. Vancomycin was changed to teicoplanin and the agranulocytosis
resolved 4 days later. However, a new episode of neutropenia, with a WBC count of 2.8× …
neutropenia induced by vancomycin therapy. Case Summary: A 57-year-old female suffered
from osteomyelitis of the left humerus, with a white blood cell (WBC) count of 2.8× 103/mm3
and absolute neutrophil count (ANC) of 0.28× 103/mm3, occurring after 24 days of
vancomycin therapy. Vancomycin was changed to teicoplanin and the agranulocytosis
resolved 4 days later. However, a new episode of neutropenia, with a WBC count of 2.8× …
Objective
To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.
Case Summary
A 57-year-old female suffered from osteomyelitis of the left humerus, with a white blood cell (WBC) count of 2.8 × 103/mm3 and absolute neutrophil count (ANC) of 0.28 × 103/mm3, occurring after 24 days of vancomycin therapy. Vancomycin was changed to teicoplanin and the agranulocytosis resolved 4 days later. However, a new episode of neutropenia, with a WBC count of 2.8 × 103/mm3 and ANC of 0.448 × 103/mm3, occurred 11 days after teicoplanin initiation. Agranulocytosis resolved 4 days following withdrawal of teicoplanin.
Discussion
Because of the close time relationship between drug administration and the development of symptoms and signs, as well as between drug withdrawal and changes in WBC count and ANC, the episodes of neutropenia were suspected to be drug related. Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs. Both reactions were categorized as probable according to the Naranjo probability scale.
Conclusions
For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.
Sage Journals以上显示的是最相近的搜索结果。 查看全部搜索结果