HDL 2 particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients

A Stefanović, J Kotur-Stevuljević, S Spasić, J Vekić… - Clinical …, 2010 - Elsevier
A Stefanović, J Kotur-Stevuljević, S Spasić, J Vekić, A Zeljković, V Spasojević-Kalimanovska…
Clinical biochemistry, 2010•Elsevier
OBJECTIVES: In this study we examined the relationship of oxidative stress and
hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in
type 2 diabetes mellitus (DM). DESIGN AND METHODS: Oxidative stress status parameters
(superoxide anion (O2−), superoxide dismutase (SOD) activity and paraoxonase (PON1)
status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle
diameters were determined by non-denaturing polyacrylamide gradient (3–31%) gel …
OBJECTIVES
In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM).
DESIGN AND METHODS
Oxidative stress status parameters (superoxide anion (O2−), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3–31%) gel electrophoresis.
RESULTS
Patients had significantly higher concentrations of oxidative stress parameter O2−(p<0.001) and antioxidative defence, SOD activity (p<0.001). Paraoxonase activity was significantly lower in diabetics (p<0.001). The PON1192 phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p<0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls.
CONCLUSIONS
The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.
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