… The overall arrangement of the three homeodomainDNA complexes is quite similar (Figure
1). Helices I and II are aligned in an antiparallel arrangement above the DNA, each spanning the …

… HD recognition, allowing the creation of more explicit recognition models for this family. The
potential for this domain to recognize … recognition properties for this family in natural systems. …

… specificity between homeodomains with similar recognition helices. We have employed …
of other homeodomain/DNA complexes. Dfd and Ubx bind to DNA with the recognition helix in …

… We describe the comprehensive characterization of homeodomain DNA-binding specificities
from a metazoan genome. The analysis of all 84 independent homeodomains from D. …

… the Gin at position 9 mutant proteins were apparently specifically ates a hydrogen bond
defective in homeodomain-DNA binding; ;en bond from N6 of they were stably expressed, as …

… role of Gln50 in the engrailed homeodomain–DNA recognition. Employing the crystal structure
of free engrailed homeodomain and homeodomain–DNA complex as a starting structure, …

… recognition of the nucleotide at the 3' end of the core motif 5'NAAN-3'. The nucleotide at the 5'
position of this core sequence is recognized by … involved in DNA recognition do not follow a …

… helix, which inserts itself into the major groove of the recognition site. In addition, the flexible
… contributing to specific homeodomain-DNA interactions. The recognition sites for most …

… Transcription factors containing the homeodomain DNA-binding motif have been found in
… of homeodomain−DNA complexes have revealed a general model of DNA recognition ( 12) …

… Although the homeodomain-DNA … In this section we try to place the homeodomain-DNA …
We discuss the role of a helices in recognition and discuss the respective roles of contacts with …