IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-γ production, and cytotoxicity of human peripheral blood lymphocyte subsets
MJ Smyth, Y Norihisa, JR Gerard, HA Young… - Cellular …, 1991 - Elsevier
The effects of IL-7 on the generation of cytolytic human peripheral blood lymphocytes (PBL)
were investigated. Induction of T-cell pore-forming protein (PFP) mRNA and cytotoxic
potential by IL-7 was both slow and minor compared with that observed in IL-2-cultured T
cells. IL-7 and suboptimal doses of IL-2 (10 U/ml) were found to costimulate PFP mRNA
expression and cytotoxic potential in T cells. Clearly, however, both IL-7 and IL-2/IL-7
induced the PFP gene expression and cytotoxic potential of CD8+ T cells and not CD4+ T …
were investigated. Induction of T-cell pore-forming protein (PFP) mRNA and cytotoxic
potential by IL-7 was both slow and minor compared with that observed in IL-2-cultured T
cells. IL-7 and suboptimal doses of IL-2 (10 U/ml) were found to costimulate PFP mRNA
expression and cytotoxic potential in T cells. Clearly, however, both IL-7 and IL-2/IL-7
induced the PFP gene expression and cytotoxic potential of CD8+ T cells and not CD4+ T …
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