Identifying miRNA-mediated signaling subpathways by integrating paired miRNA/mRNA expression data with pathway topology
AG Vrahatis, GN Dimitrakopoulos… - 2015 37th Annual …, 2015 - ieeexplore.ieee.org
2015 37th Annual International Conference of the IEEE Engineering …, 2015•ieeexplore.ieee.org
In the road for network medicine the newly emerged systems-level subpathway-based
analysis methods offer new disease genes, drug targets and network-based biomarkers. In
parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the
micronome effect upon the signaling pathways. Towards this orientation, we present a
methodological pipeline for the identification of differentially expressed subpathways along
with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target …
analysis methods offer new disease genes, drug targets and network-based biomarkers. In
parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the
micronome effect upon the signaling pathways. Towards this orientation, we present a
methodological pipeline for the identification of differentially expressed subpathways along
with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target …
In the road for network medicine the newly emerged systems-level subpathway-based analysis methods offer new disease genes, drug targets and network-based biomarkers. In parallel, paired miRNA/mRNA expression data enable simultaneously monitoring of the micronome effect upon the signaling pathways. Towards this orientation, we present a methodological pipeline for the identification of differentially expressed subpathways along with their miRNA regulators by using KEGG signaling pathway maps, miRNA-target interactions and expression profiles from paired miRNA/mRNA experiments. Our pipeline offered new biological insights on a real application of paired miRNA/mRNA expression profiles with respect to the dynamic changes from colostrum to mature milk whey; several literature supported genes and miRNAs were recontextualized through miRNA-mediated differentially expressed subpathways.
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