… antifungal immunity. We emphasize the role of different anatomic sites and cellular crosstalk
in maintaining sterilizing anti-fungal immunity in the lung and in the pathogenesis of fungus-…

… and chemokines, which are predominant regulators in the infectious microenvironment,
mediating the cellular and molecular immune responses against a fungal infection in the lung. …

… exuberant immune response to harmless fungal antigens. This review will discuss several
aspects of barrier immunity to pulmonary fungal infection, as well as situations where fungal …

… of lung monocytes and macrophages to mediate fungal killing. Another study pointed to
CCL2-dependent pulmonary natural killer cell recruitment as a protective mechanism against …

… hosts fungi can colonize and infect the lungs and other organs, causing increases in
morbidity and mortality. Alternatively, fungi and their products can cause exaggerated immune …

… For example, humans inhale infectious conidia or desiccated fungal cells of all genera listed
under lungs and respiratory tree. For other sites, such as the liver, spleen, and blood stream…

… immune responses in the development of an optimal antifungal immunity and, in particular,
the improved definition of fungal … Fungal growth of spores in the lung or the skin produces …

… , in the lung, which is often the primary route of infection for fungi, but not in the skin or the
spleen, monocyte-derived DCs play a critical and indispensable role in antifungal immunity. …

… priming Th1 cells in the lung in response to these fungi (66, 70). CCR2 −/− mice exhibit
skewed Th2 responses and dramatically greater fungal burden in the lung compared with wild-…

… , unrestricted fungal … on fungal burden. The capacity of regulatory T cells (Tregs) to inhibit
aspects of innate and adaptive antifungal immunity is required for protective tolerance to fungi. …