Two distinct types of vulvar squamous cell carcinomas and their precursors, vulvar
intraepithelial neoplasias (VIN), which differ in terms of clinical presentation and behavior,
have been delineated. Human papillomavirus (HPV)-associated carcinomas are of basaloid
or warty type, whereas tumors unrelated to HPV are usually keratinizing and differentiated.
Thus, the major stratifying factor for vulvar carcinomas and VIN is their etiopathogenetic
relationship with HPV. However, because of technical difficulties in confidently detecting …