In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis
GS Li, WL Jiang, JW Tian, GW Qu, HB Zhu, FH Fu - Phytomedicine, 2010 - Elsevier
This study was carried out to investigate whether rosmarinic acid (RA) has antifibrotic effect
on experimental liver fibrosis in vitro and in vivo and its possible mechanism. Culture of
hepatic stellate cells (HSCs) determine proliferation and expression of transforming growth
factor-β1 (TGF-β1), connective transforming growth factor (CTGF) and α-smooth muscle
actin (α-SMA). In carbon tetrachloride (CCL4)-induced rat liver fibrosis model, determined
biochemical indicator, liver fibrosis grade and histopathological changes …
on experimental liver fibrosis in vitro and in vivo and its possible mechanism. Culture of
hepatic stellate cells (HSCs) determine proliferation and expression of transforming growth
factor-β1 (TGF-β1), connective transforming growth factor (CTGF) and α-smooth muscle
actin (α-SMA). In carbon tetrachloride (CCL4)-induced rat liver fibrosis model, determined
biochemical indicator, liver fibrosis grade and histopathological changes …
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